Synonyms. Mabron, Sintradon, Tramal.
The composition and the form of output. Tramadol hydrochloride capsules of 0.05 g; Drop reception inside, containing 0,1-in-1 ml; Solution in 1 ml ampoule containing 0.05 g of product; Candles of 0.1 d. Indications. Acute and chronic pain: in the postoperative period, with injuries to cancer patients; Sedation.
Pharmacological effects. Tramadol drug-central action of the agonistam- opioid receptor antagonists, has expressed activity and is a quick and lasting impact. By activity doses of morphine he assigns. Features of Step is a type of hybrid: a selective agonist of the net opioid-receptor stimulates Mu - he, and Delta Kappa receptors, but has a higher affinity for the Mu-receptors. Another mechanism involved effect, a reverse takeover noradrenalina inhibition and serotonin in neurons. Centers like morphine oppresses propulsion and sensitive response spinal system. In therapeutic doses get Its effect is, making contact with Mu-opioid receptors, but does not cause respiratory depression and does not affect Motoric bowel.
Contraindications.
Increased sensitivity to the drug, acute alcohol intoxication, acute poison pills, analgeticheskimi and other means, oppressive agent. Unwanted reactions in conjunction with other drugs. Carbamazepine, a coil mikrosomalnyh liver enzymes, reduces the effect analgeziruyuschy Step in their joint application. Centers, ingibiruya reverse takeover noradrenalina and serotonin, in a joint application with MAO inhibitors or reverse takeover antidepressantami- inhibitors and serotonin noradrenalina leads to toxic interactions. Chemical compatibility notes in the introduction of a syringe products and solutions diklofenaka sodium or depression, or fenilbutazona, or diazepam, or flunitrazepama, or nitroglycerin. Information for the patient. Adults assign capsules to 0.05 grams per reception, increasing dose up to 8 capsules per day (0.4 g), depending on the nature and vyrazhennosti pain syndrome. Take preparation for 30-40 minutes before the meal, vine little liquid. Missing dose: accept the product as soon as possible; Do not take it even if, before the subsequent doses of time; Do not take a double dose. After a parenteral Step gently change of the body from the horizontal to the vertical. Avoid alcohol. Patients older than 75 years dose Step limited to 0.3 grams per day. Not recommended drug persons suffering from drug dependence on opiates.
